Article
Distinct roles of the Pumilio and FBF translational repressors during C. elegans vulval development.
Development (Cambridge, England) - 1 Sept 2006
Walser Claudia B, Battu Gopal, Hoier Erika Fröhli, Hajnal Alex
Abstract excerpt
The C. elegans PUF and FBF proteins regulate various aspects of germline development by selectively binding to the 3' untranslated region of their target mRNAs and repressing translation. Here, we show that puf-8, fbf-1 and fbf-2 also act in the soma where they negatively regulate vulvaI development. Loss-of-function mutations in puf-8 cause ectopic vulval differentiation when combined with mutations in negative...
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