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Article

Multiple elements in the promoter of granulocyte colony-stimulating factor gene regulate its constitutive expression in human carcinoma cells.

The Journal of biological chemistry - 5 Apr 1990

Nishizawa M, Tsuchiya M, Watanabe-Fukunaga R, Nagata S

Abstract excerpt

Some human carcinoma cells constitutively produce granulocyte colony-stimulating factor (G-CSF) which stimulates the proliferation and differentiation of the progenitor cells of neutrophilic granulocytes. By introducing mouse G-CSF chromosomal gene or its promoter DNA into human carcinoma cell lines of CHU-2, SK-HEP-1, and U-87MG, it was shown that the constitutive expression of G-CSF in these carcinoma cells was...

Topics

Adenocarcinoma
Animals
Base Sequence
Carcinoma, Squamous Cell
Colony-Stimulating Factors
Deoxyribonuclease BamHI
Deoxyribonucleases, Type II Site-Specific
Gene Expression Regulation
Glioma
Granulocyte Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mice

Molecular Sequence Data

Mutation

Neoplasms

Plasmids

Promoter Regions, Genetic

Regulatory Sequences, Nucleic Acid

Source

Identifiers

PMID: 1690717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1690717-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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