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Article

Role of a STAT Binding Site in the Regulation of the Human Perforin Promoter

1 Mar 1999

Abstract excerpt

The pore-forming protein perforin is preferentially expressed in NK and cytotoxic T cells. To investigate the molecular regulation of human perforin gene transcription, the activity of the human perforin promoter was analyzed in human NK and T cell lines using various promoter fragments linked to a luciferase reporter gene. A core promoter was identified within 55 bp upstream of the transcription start site. This...

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Identifiers

PMID: 10072525
DOI: 10.4049/jimmunol.162.5.2785

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Source receipt: pubmed, retrieved 7 Sept 2026.

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