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Article

An <i>In vivo</i> Platform for Translational Drug Development in Pancreatic Cancer

1 Aug 2006

Abstract excerpt

Effective development of targeted anticancer agents includes the definition of the optimal biological dose and biomarkers of drug activity. Currently available preclinical models are not optimal to this end. We aimed at generating a model for translational drug development using pancreatic cancer as a prototype. Resected pancreatic cancers from 14 patients were xenografted and expanded in successive groups of...

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PMID: 16899615
DOI: 10.1158/1078-0432.ccr-06-0113

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