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Article

Development and characterization of a colon PDX model that reproduces drug responsiveness and the mutation profiles of its original tumor.

Cancer letters - 1 Apr 2014

Seol Hyang Sook, Kang Hyo Jeong, Kang Hyojeong, Lee Seul-I, Kim Na Eun, Kim Tae Im, Chun Sung Min, Kim Tae Won, Yu Chang Sik, Suh Young-Ah, Singh Shree Ram, Chang Suhwan, Jang Se Jin

Abstract excerpt

Cultures of primary tumors are very useful as a personalized screening system for effective therapeutic options. We here describe an effective method of reproducing human primary colon tumors through primary culture and a mouse xenograft model. A total of 199 primary colon tumor cultures were successfully established under optimized conditions to enrich for tumor cells and to expand it for long-term storage in...

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Identifiers

PMID: 24333725
DOI: 10.1016/j.canlet.2013.11.010
PMCID: PMC7672533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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