Article
Induction of mesenchymal cell phenotypes in lung epithelial cells by adenovirus E1A.
The European respiratory journal - 1 Dec 2006
Behzad A R, Morimoto K, Gosselink J, Green J, Hogg J C, Hayashi S
Abstract excerpt
Epithelial-mesenchymal transformation is now recognised as an important feature of tissue remodelling. The present report concerns the role of adenovirus infection in inducing this transformation in an animal model of chronic obstructive pulmonary disease. Guinea pig primary peripheral lung epithelial cells (PLECs) transfected with adenovirus E1A (E1A-PLECs) were compared to guinea pig normal lung fibroblasts...
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