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Article

Adenovirus-5 E1A suppresses differentiation of 3T3 L1 preadipocytes at lower levels than required for induction of apoptosis.

Molecular carcinogenesis - 1 May 2005

Cao Jun, Arulanandam Rozanne, Vultur Adina, Preston Thomas, Jaronczyk Katarzyna, Tomai Evangelia, Zandi Keivan, Raptis Leda

Abstract excerpt

To investigate the functional relationship between the ability of the adenovirus-5 E1A oncogene product to transform with its ability to block adipocytic differentiation and induce apoptosis, we expressed E1A in the 3T3 L1 preadipocytic cell line. The results demonstrate a dramatic, quantitative reciprocal regulation of differentiation and several transformation-associated properties in response to graded levels...

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PMID: 15768386
DOI: 10.1002/mc.20078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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