Article
Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi.
Mucosal immunology - 1 Jul 2014
Bacher P, Kniemeyer O, Schönbrunn A, Sawitzki B, Assenmacher M, Rietschel E, Steinbach A, Cornely O A, Brakhage A A, Thiel A, Scheffold A
Abstract excerpt
Foxp3(+) regulatory T cells (Treg) have a central role for keeping the balance between pro- and anti-inflammatory immune responses against chronically encountered antigens at mucosal sites. However, their antigen specificity especially in humans is largely unknown. Here we used a sensitive enrichment technology for antigen-reactive T cells to directly compare the conventional vs. regulatory CD4(+) T-cell response...
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