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Treg in inborn errors of immunity: gaps, knowns and future perspectives.

Frontiers in immunology - 1 Jan 2023

Kennedy-Batalla Rebeca, Acevedo Daniel, Luo Yiyi, Esteve-Solé Ana, Vlagea Alexandru, Correa-Rocha Rafael, Seoane-Reula Ma Elena, Alsina Laia

Abstract excerpt

Regulatory T cells (Treg) are essential for immune balance, preventing overreactive responses and autoimmunity. Although traditionally characterized as CD4+CD25+CD127lowFoxP3hi, recent research has revealed diverse Treg subsets such as Tr1, Tr1-like, and CD8 Treg. Treg dysfunction leads to severe autoimmune diseases and immune-mediated inflammatory disorders. Inborn errors of immunity (IEI) are a group of...

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Identifiers

PMID: 38259469
DOI: 10.3389/fimmu.2023.1278759
PMCID: PMC10800401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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