Crystal structure of the tyrosine kinase domain of the human insulin receptor.

doi:10.1038/372746a0

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Article

Crystal structure of the tyrosine kinase domain of the human insulin receptor.

Nature - 1 Jan 2000

Hubbard S R, Wei L, Ellis L, Hendrickson W A

Abstract excerpt

The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine...

Topics

Amino Acid Sequence
Binding Sites
Computer Graphics
Conserved Sequence
Crystallography, X-Ray
Diabetes Mellitus, Type 2
Enzyme Activation
Humans
Molecular Sequence Data
Mutation
Phosphorylation
Protein Conformation
Receptor, Insulin
Recombinant Proteins
Substrate Specificity
Tyrosine

Source

Open in PubMed

Identifiers

PMID: 7997262
DOI: 10.1038/372746a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7997262-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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