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Article

Crystal structure of the tyrosine kinase domain of the human insulin receptor.

Nature - 1 Jan 2000

Hubbard S R, Wei L, Ellis L, Hendrickson W A

Abstract excerpt

The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin,...

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PMID: 7997262
DOI: 10.1038/372746a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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