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Article

Transforming properties of <i>YAP</i> , a candidate oncogene on the chromosome 11q22 amplicon

7 Aug 2006

Abstract excerpt

In a screen for gene copy-number changes in mouse mammary tumors, we identified a tumor with a small 350-kb amplicon from a region that is syntenic to a much larger locus amplified in human cancers at chromosome 11q22. The mouse amplicon contains only one known gene, Yap, encoding the mammalian ortholog of Drosophila Yorkie (Yki), a downstream effector of the Hippo(Hpo)-Salvador(Sav)-Warts(Wts) signaling cascade,...

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PMID: 16894141
DOI: 10.1073/pnas.0605579103

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Related research

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Transforming properties of <i>YAP</i> , a candidate oncogene on the chromosome 11q22 ampliconPMID 16894141Read ↗

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Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the <i>Drosophila Hippo</i> PathwaySemantic proximity Read ↗

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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.Semantic proximity Read ↗

YAP1 Dysfunction Promotes Molecular Properties Linked to Breast Cancer Susceptibility.Semantic proximity Read ↗

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.Semantic proximity Read ↗

Hippo pathway effectors YAP1/TAZ induce a EWS-FLI1-opposing gene signature and associate with disease progression in Ewing SarcomaSemantic proximity Read ↗

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