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Article

Hippo pathway effector Yap is an ovarian cancer oncogene.

Cancer research - 1 Nov 2010

Hall Chad A, Wang Runsheng, Miao Jiangyong, Oliva Esther, Shen Xiaoyun, Wheeler Thomas, Hilsenbeck Susan G, Orsulic Sandra, Goode Scott

Abstract excerpt

The Hippo pathway regulates organ size and tumorigenesis in Drosophila and mammals and is altered in a variety of human cancers, yet it remains unclear if the Hippo pathway is of prognostic significance to cancer patients. Here we show that the key targets of Hippo signaling, transcriptional coactivators Yki and Yap, play a conserved role in promoting ovarian cancer in flies and humans, respectively. Whereas...

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Identifiers

PMID: 20947521
DOI: 10.1158/0008-5472.CAN-10-1242
PMCID: PMC2970655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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