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Article

Sex-biased <i>Yap1</i> oncogene function

2022-12-22

Abstract excerpt

<h4>ABSTRACT</h4> The incidence of many human cancers differs according to sex, but little is known about the interplay between oncogenic events and sex as a variable in tumorigenesis. Here we report that the oncogene Yap1 is sexually dimorphic in medulloblastoma progression and immune suppression. We show that Yap1 promotes stemness and blocks differentiation in sonic hedgehog (SHH)-subtype medulloblastoma by...

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Identifiers and source

Literature Corpus work
58294912-230a-5f9d-960e-6fbd61c8dbc6
DOI
10.1101/2022.12.21.521494
Open publication

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Sex-biased <i>Yap1</i> oncogene functionDOI 10.1101/2022.12.21.521494
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