Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease.

Journal of neurochemistry - 1 Feb 2008

Weiss Andreas, Klein Corinna, Woodman Ben, Sathasivam Kirupa, Bibel Miriam, Régulier Etienne, Bates Gillian P, Paganetti Paolo

Abstract excerpt

A CAG-repeat gene expansion translated into a pathogenic polyglutamine stretch at the N-terminus of huntingtin triggers Huntington's Disease. Mutated huntingtin is predicted to adopt toxic properties mainly if aggregation-prone N-terminal fragments are released by proteolysis. Huntingtin-aggregates are indeed a major hallmark of this disorder and could represent useful markers of disease-onset or progression. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corpus Striatum
Share to Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Huntingtin Protein

Share to Huntington Disease

Share to Neurons

Share to Subcellular Fractions

Share to Trinucleotide Repeat Expansion

Source

Identifiers

PMID: 17986219
DOI: 10.1111/j.1471-4159.2007.05032.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease.PMID 17986219Read ↗

Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington’S Disease ModelSemantic proximity Read ↗

Huntington's disease: from pathology and genetics to potential therapies.Semantic proximity Read ↗

An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity.Semantic proximity Read ↗

A Review On Huntington Protein: Insight Into Protein Aggregation and Therapeutic Interventions.Semantic proximity Read ↗

Pathogenesis of polyglutamine disorders: aggregation revisitedSemantic proximity Read ↗

Monomeric, Oligomeric and Polymeric Proteins in Huntington Disease and Other Diseases of Polyglutamine ExpansionSemantic proximity Read ↗

A molecular investigation of true dominance in Huntington's disease.Semantic proximity Read ↗

Huntingtin aggregation and toxicity in Huntington's diseaseSemantic proximity Read ↗

Protein aggregation in motor neurone disorders.Semantic proximity Read ↗

Protein Aggregation and Pathogenesis of Huntingtons Disease: Mechanisms and CorrelationsSemantic proximity Read ↗

Characterization of proteins associated with polyglutamine aggregates: a novel approach towards isolation of aggregates from protein conformation disorders.Semantic proximity Read ↗

Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platformsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.