Article
CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA.
FEBS letters - 10 Apr 2002
Gorbunova Vera, Seluanov Andrei
Abstract excerpt
Mutations in the clk-1 gene of Caenorhabditis elegans extend worm life span and slow down a variety of physiological processes. Here we report that C. elegans CLK-1 as well as its mouse homologue have DNA binding activity that is specific to the O(L) region of mitochondrial DNA. DNA binding activity of CLK-1 is inhibited by ADP, and is altered by mutations that extend nematode life span. Our results suggest that,...
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