Article
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.
Science (New York, N.Y.) - 14 Feb 1997
Ewbank J J, Barnes T M, Lakowski B, Lussier M, Bussey H, Hekimi S
Abstract excerpt
Mutations in the Caenorhabditis elegans gene clk-1 affect biological timing and extend longevity. The gene clk-1 was identified, and the cloned gene complemented the clk-1 phenotypes and restored normal longevity. The CLK-1 protein was found to be conserved among eukaryotes, including humans, and structurally similar to the yeast metabolic regulator Cat5p (also called Coq7p). These proteins contain a tandem...
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