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Article

Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin <i>in vivo</i>

8 May 2006

Abstract excerpt

BACKGROUND: Individuality in the expression and regulation of hepatic drug-metabolizing enzymes (DMEs) and cytoprotective (CP) genes is an important determinant of treatment response. There is increasing evidence that many DMEs and CP genes are also expressed in human skin. Responses to topical drugs used to treat common skin diseases, such as psoriasis, are unpredictable and may potentially be rationalized, at...

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PMID: 16882163
DOI: 10.1111/j.1365-2133.2006.07317.x

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