Expression and enzyme activity of cytochrome P450 enzymes CYP 3A4 and CYP 3A5 in human skin and tissue‐engineered skin equivalents

Abstract excerpt

CYP3A4 and CYP4A5 share specificity for a wide range of xenobiotics with the CYP3 subfamily collectively involved in the biotransformation of approximately 30% of all drugs. CYP3A4/5 mRNA transcripts have been reported in the skin, yet knowledge of their protein expression and function is lacking. In this study, we observed gene and protein expression of CYP3A4/5 in both human skin and tissue-engineered skin...

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