Article

Determinants of transcriptional regulation of transport and oxidative processes in human model systems

2013-01-01

Abstract excerpt

Initial predictions of drug response and drug-drug interactions (DDIs) are made following high-throughput in vitro screening. Such assays are indispensible in the pharmaceutical industry to determine the metabolism, transport and pharmacokinetics of new chemical entities. However, they often fail when extrapolated to in vivo response due to unsuitable pharmacokinetic or pharmacodynamic prediction. The primary aim...

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Literature Corpus work: 712e8b07-b02a-5446-a6a0-4b08a438e122
DOI: 10.17638/00015053

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