Article
Synthesis of phosphatidylcholine, a typical eukaryotic phospholipid, is necessary for full virulence of the intracellular bacterial parasite Brucella abortus.
Cellular microbiology - 1 Aug 2006
Conde-Alvarez Raquel, Grilló María J, Salcedo Suzana P, de Miguel María J, Fugier Emilie, Gorvel Jean Pierre, Moriyón Ignacio, Iriarte Maite
Abstract excerpt
Phosphatidylcholine (PC) is a typical eukaryotic phospholipid absent from most prokaryotes. Thus, its presence in some intracellular bacteria is intriguing as it may constitute host mimicry. The role of PC in Brucella abortus was examined by generating mutants in pcs (BApcs) and pmtA (BApmtA), which encode key enzymes of the two bacterial PC biosynthetic routes, the choline and methyl-transferase pathways. In...
Topics
- Animals
- Bacterial Proteins
- Base Sequence
- Brucella abortus
- Cell Membrane
- DNA, Bacterial
- Female
- Genes, Bacterial
- In Vitro Techniques
- Macrophages