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Trehalose polyphleates participate in Mycobacterium abscessus fitness and pathogenesis

30 Oct 2024

Abstract excerpt

ABSTRACT Mycobacteria produce a large repertoire of surface-exposed lipids with major biological functions. Among these lipids, trehalose polyphleates (TPPs) are instrumental in the infection of Mycobacterium abscessus by the therapeutic phage BPs. However, while the biosynthesis and transport of TPPs across the membrane by MmpL10 have been reported, the role of TPPs in host infection remains enigmatic. Here, we...

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PMID: 39475242
DOI: 10.1128/mbio.02970-24

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