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Genetic diversity of Legionella pcs and pmtA genes and the effect of utilization of choline by Legionella spp. on induction of proinflammatory cytokines.

Pathogens and disease - 1 Oct 2019

Palusińska-Szysz Marta, Szuster-Ciesielska Agnieszka, Janczarek Monika, Wdowiak-Wróbel Sylwia, Schiller Jürgen, Reszczyńska Emilia, Gruszecki Wiesław I, Fuchs Beate

Abstract excerpt

Legionella species synthesize phosphatidylcholine (PC) in two independent pathways: the three-step methylation of phosphatidylethanolamine PMT pathway and the one-step PCS pathway, in which the Pcs enzyme catalyzes the reaction between choline and CDP-diacylglycerol to form PC. Legionella pcs genes encode highly hydrophobic proteins with phosphatidylcholine synthase activity, which contain up to eight...

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PMID: 31778176
DOI: 10.1093/femspd/ftz065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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