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Article

Lysosomal phospholipase A2 and phospholipidosis.

Molecular and cellular biology - 1 Aug 2006

Hiraoka Miki, Abe Akira, Lu Ye, Yang Kui, Han Xianlin, Gross Richard W, Shayman James A

Abstract excerpt

A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine. LPLA2 is ubiquitously expressed but is most highly expressed in alveolar macrophages. Double conditional gene targeting was employed to elucidate the function of LPLA2. LPLA2-deficient mice (Lpla2-/-) were generated by the systemic deletion of exon 5 of the...

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Identifiers

PMID: 16880524
DOI: 10.1128/MCB.00627-06
PMCID: PMC1592808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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