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Article

Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase.

The Journal of biological chemistry - 22 Mar 2002

Hiraoka Miki, Abe Akira, Shayman James A

Abstract excerpt

Recently, a novel enzyme, 1-O-acylceramide synthase (ACS), was purified and characterized from bovine brain. This enzyme has both calcium-independent phospholipase A(2) and transacylase activities. The discovery of this enzyme led us to propose a new pathway for ceramide metabolism in which the sn-2-acyl group of either phosphatidylethanolamine or phosphatidylcholine is transferred to the 1-hydroxyl group of...

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Identifiers

PMID: 11790796
DOI: 10.1074/jbc.M111977200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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