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Article

Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2.

Journal of lipid research - 1 Jun 2005

Fisher Aron B, Dodia Chandra, Feinstein Sheldon I, Ho Ye-Shih

Abstract excerpt

Lung surfactant dipalmitoylphosphatidylcholine (DPPC) is endocytosed by alveolar epithelial cells and degraded by lysosomal-type phospholipase A2 (aiPLA2). This enzyme is identical to peroxiredoxin 6 (Prdx6), a bifunctional protein with PLA2 and GSH peroxidase activities. Lung phospholipid was studied in Prdx6 knockout (Prdx6-/-) mice. The normalized content of total phospholipid, phosphatidylcholine (PC), and...

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Identifiers

PMID: 15772425
DOI: 10.1194/jlr.M400499-JLR200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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