Article
Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants.
Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 1999
Madhani H D, Galitski T, Lander E S, Fink G R
Abstract excerpt
Despite the importance of mitogen-activated protein kinase (MAPK) signaling in eukaryotic biology, the mechanisms by which signaling yields phenotypic changes are poorly understood. We have combined transcriptional profiling with genetics to determine how the Kss1 MAPK signaling pathway controls dimorphic development in Saccharomyces cerevisiae. This analysis identified dozens of transcripts that are regulated by...
Topics
- Cyclins
- Haploidy
- MAP Kinase Signaling System
- Mutation
- Nucleic Acid Hybridization
- RNA, Messenger
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins