Article
Role of a VPS41 homologue in starvation response, intracellular survival and virulence of Cryptococcus neoformans.
Molecular microbiology - 1 Sept 2006
Liu Xiaoguang, Hu Guowu, Panepinto John, Williamson Peter R
Abstract excerpt
Previous studies have demonstrated an important role for the vacuole in the virulence of the fungus Cryptococcus and studies in yeast have implicated the vacuolar protein Vps41 in copper loading of proteins such as iron transporters. However, our studies found that a cryptococcal vps41Delta strain displayed wild-type growth on media containing iron and copper chelators and normal activity of the copper-containing...
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