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The vacuolar Ca²(+) exchanger Vcx1 is involved in calcineurin-dependent Ca²(+) tolerance and virulence in Cryptococcus neoformans.

Eukaryotic cell - 1 Nov 2010

Kmetzsch Lívia, Staats Charley Christian, Simon Elisa, Fonseca Fernanda L, de Oliveira Débora L, Sobrino Luna, Rodrigues Jéssica, Leal Ana Lusia, Nimrichter Leonardo, Rodrigues Márcio L, Schrank Augusto, Vainstein Marilene Henning

Abstract excerpt

Cryptococcus neoformans is an encapsulated yeast that causes a life-threatening meningoencephalitis in immunocompromised individuals. The ability to survive and proliferate at the human body temperature is an essential virulence attribute of this pathogen. This trait is controlled in part by the Ca²(+)-calcineurin pathway, which senses and utilizes cytosolic calcium for signaling. In the present study, the...

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Identifiers

PMID: 20889719
DOI: 10.1128/EC.00114-10
PMCID: PMC2976299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The vacuolar Ca²(+) exchanger Vcx1 is involved in calcineurin-dependent Ca²(+) tolerance and virulence in Cryptococcus neoformans.PMID 20889719Read ↗

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