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Article

Cryptococcus neoformans requires the ESCRT protein Vps23 for iron acquisition from heme, for capsule formation, and for virulence.

Infection and immunity - 1 Jan 2013

Hu Guanggan, Caza Mélissa, Cadieux Brigitte, Chan Vivienne, Liu Victor, Kronstad James

Abstract excerpt

Iron availability is a key regulator of virulence factor elaboration in Cryptococcus neoformans, the causative agent of fungal meningoencephalitis in HIV/AIDS patients. In addition, iron is an essential nutrient for pathogen proliferation in mammalian hosts but little is known about the mechanisms of iron sensing and uptake in fungal pathogens that attack humans. In this study, we mutagenized C. neoformans by...

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Identifiers

PMID: 23132495
DOI: 10.1128/IAI.01037-12
PMCID: PMC3536123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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