Conserved Autophagy Pathway Contributes to Stress Tolerance and Virulence and Differentially Controls Autophagic Flux Upon Nutrient Starvation in Cryptococcus neoformans

Abstract excerpt

Cryptococcus neoformans is a major fungal pathogen primarily infecting immunocompromised hosts. Autophagy is mainly a catabolic process induced by and coping with nutrient deficiency and various stressful conditions. Human environment often imposes various stresses to C. neoformans and therefore, autophagic responsiveness of C. neoformans to these stresses often decides its survival in host. However, a systematic...

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