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Article

Candida albicans VPS4 contributes differentially to epithelial and mucosal pathogenesis.

Virulence - 1 Jan 2014

Rane Hallie S, Hardison Sarah, Botelho Claudia, Bernardo Stella M, Wormley Floyd, Lee Samuel A

Abstract excerpt

We have previously demonstrated that the C. albicans pre-vacuolar protein sorting gene VPS4 is required for extracellular secretion of the secreted aspartyl proteases Sap2p and Saps4-6p. Furthermore, the vps4Δ null mutant has been shown to be markedly hypovirulent in a murine tail vein model of disseminated candidiasis. In these experiments, we sought to further define the role of the pre-vacuolar secretion...

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Identifiers

PMID: 25483774
DOI: 10.4161/21505594.2014.956648
PMCID: PMC4601185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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