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Article

Role of the ESCRT Pathway in Laccase Trafficking and Virulence of Cryptococcus neoformans.

Infection and immunity - 22 Jun 2020

Park Yoon-Dong, Chen Shu Hui, Camacho Emma, Casadevall Arturo, Williamson Peter R

Abstract excerpt

The endosomal sorting complex required for transport (ESCRT) plays a crucial role in the transportation and degradation of proteins. We determined that Vps27, a key protein of the ESCRT-0 complex, is required for the transport of the virulence factor laccase to the cell wall in Cryptococcus neoformans Laccase activity was perturbed, as was melanin production, in vps27Δ strains. In the absence of VPS27, there was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32284371
DOI: 10.1128/IAI.00954-19
PMCID: PMC7309605

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