Article
Hepatic lipase (LIPC) promoter polymorphism in men with coronary artery disease. Allele frequency and effects on hepatic lipase activity and plasma HDL-C concentrations.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 1999
Shohet R V, Vega G L, Anwar A, Cigarroa J E, Grundy S M, Cohen J C
Abstract excerpt
Hepatic lipase is an important determinant of plasma HDL concentration and LDL subclass distribution and may therefore influence susceptibility to coronary artery disease (CAD). To assess the effect of genetic variation in hepatic lipase activity on CAD susceptibility, we determined the frequency of the -514T allele of hepatic lipase in white men with CAD and in controls who did not have CAD. In men with CAD,...
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