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Article

Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation.

The American journal of pathology - 1 Aug 2006

Tormo Damia, Ferrer Aleix, Gaffal Evelyn, Wenzel Jörg, Basner-Tschakarjan Etiena, Steitz Julia, Heukamp Lukas C, Gütgemann Ines, Buettner Reinhard, Malumbres Marcos, Barbacid Mariano, Merlino Glenn, Tüting Thomas

Abstract excerpt

Currently, novel mouse models of melanoma are being generated that recapitulate the histopathology and molecular pathogenesis observed in human disease. Impaired cell-cycle control, which is a hallmark of both familial and sporadic melanoma, promotes slowly growing carcinogen-induced melanomas in the skin of mice carrying a mutated cyclin-dependent kinase 4 (CDK4(R24C)). Deregulated receptor tyrosine kinase...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16877364
DOI: 10.2353/ajpath.2006.060017
PMCID: PMC1698803

Genes

CDK4
HGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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