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Article

A murine model for the development of melanocytic nevi and their progression to melanoma.

Molecular carcinogenesis - 1 May 2016

Nasti Tahseen H, Cochran J Barry, Tsuruta Yuko, Yusuf Nabiha, McKay Kristopher M, Athar Mohammad, Timares Laura, Elmets Craig A

Abstract excerpt

Acquired melanocytic nevi are commonly found in sun exposed and unexposed human skin, but the potential for their transformation into invasive melanoma is not clear. Therefore, a mouse model of nevus initiation and progression was developed in C3H/HeN mice using a modified chemical carcinogenesis protocol. Nevi develop due to DNA damage initiated by dimethylbenz(a) anthracene (DMBA) followed by chronic promotion...

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Identifiers

PMID: 25788145
DOI: 10.1002/mc.22310
PMCID: PMC4575238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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