Article
Invasive melanoma in Cdk4-targeted mice.
Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2001
Sotillo R, García J F, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M
Abstract excerpt
Many human tumors harbor mutations that result in deregulation of Cdk4 activity. Most of these mutations involve overexpression of D-type cyclins and inactivation of INK4 inhibitors. In addition, a mutation in the Cdk4 protein has been described in patients with familial melanoma (Wolfel, T., Hauer, M., Schneider, J., Serrano, M., Wolfel, C., et al. (1995) Science 269, 1281-1284; Zuo, L., Weger, J., Yang, Q.,...
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