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Article

Joint regulation of the nmt1 promoter and sporulation by Thi1 and Thi5 in Schizosaccharomyces pombe.

Current genetics - 1 Oct 2006

McQuire Tracy A, Young Paul G

Abstract excerpt

nmt1 in fission yeast is essential for thiamine biosynthesis and is regulated by the thi1 transcription factor. The thiamine-repressible nmt1 promoter is the most widely used promoter construct for gene expression studies in fission yeast. We show that in addition to thi1, thi5 also regulates the nmt1 promoter and its expression is undetectable in a thi1 thi5 double deletion. Thi5 over-expression relieves the...

Topics

Amino Acid Sequence
DNA-Binding Proteins
Gene Deletion
Gene Expression Regulation, Fungal
Molecular Sequence Data
Phenotype
Promoter Regions, Genetic
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Sequence Alignment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spores, Fungal

Thiamine

Transcription Factors

Source

Identifiers

PMID: 16874521
DOI: 10.1007/s00294-006-0086-x

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