Article
Dual role for the yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance.
Journal of molecular biology - 17 Oct 1997
Machado C R, Praekelt U M, de Oliveira R C, Barbosa A C, Byrne K L, Meacock P A, Menck C F
Abstract excerpt
The THI4 gene of Saccharomyces cerevisiae encodes an enzyme of the thiamine biosynthetic pathway. The plant homolog thi1, from Arabidopsis thaliana, is also involved in thiamine biosynthesis; but was originally cloned due to its capacity to complement DNA repair deficient phenotypes in Escherichia coli. Here, the behavior of a thi4 disrupted strain was examined for increased sensitivity to treatment with the DNA...
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