Article
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2006
Kannankeril Prince J, Mitchell Brett M, Goonasekera Sanjeewa A, Chelu Mihail G, Zhang Wei, Sood Subeena, Kearney Debra L, Danila Cristina I, De Biasi Mariella, Wehrens Xander H T, Pautler Robia G, Roden Dan M, Taffet George E, Dirksen Robert T, Anderson Mark E, Hamilton Susan L
Abstract excerpt
Mutations in the cardiac ryanodine receptor 2 (RyR2) have been associated with catecholaminergic polymorphic ventricular tachycardia and a form of arrhythmogenic right ventricular dysplasia. To study the relationship between RyR2 function and these phenotypes, we developed knockin mice with the human disease-associated RyR2 mutation R176Q. Histologic analysis of hearts from RyR2(R176Q/+) mice revealed no evidence...
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