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Article

Isoform-dependent interaction of voltage-gated sodium channels with protons.

The Journal of physiology - 15 Oct 2006

Khan A, Kyle J W, Hanck D A, Lipkind G M, Fozzard H A

Abstract excerpt

Protons are potent physiological modifiers of voltage-gated Na(+) channels, shifting the voltage range of channel gating and reducing current magnitude (pK(a) approximately 6). We recently showed that proton block of the skeletal muscle isoform (Na(V)1.4) resulted from protonation of the four superficial carboxylates in the outer vestibule of the channel. We concluded that the large local negative electrostatic...

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Identifiers

PMID: 16873405
DOI: 10.1113/jphysiol.2006.115659
PMCID: PMC1890365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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