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Article

A Na+ channel mutation linked to hypokalemic periodic paralysis exposes a proton-selective gating pore.

The Journal of general physiology - 1 Jul 2007

Struyk Arie F, Cannon Stephen C

Abstract excerpt

The heritable muscle disorder hypokalemic periodic paralysis (HypoPP) is characterized by attacks of flaccid weakness, brought on by sustained sarcolemmal depolarization. HypoPP is genetically linked to missense mutations at charged residues in the S4 voltage-sensing segments of either CaV1.1 (the skeletal muscle L-type Ca(2+) channel) or NaV1.4 (the skeletal muscle voltage-gated Na(+) channel). Although these...

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Identifiers

PMID: 17591984
DOI: 10.1085/jgp.200709755
PMCID: PMC2154364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Na+ channel mutation linked to hypokalemic periodic paralysis exposes a proton-selective gating pore.PMID 17591984Read ↗

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