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Article

Genetic and biochemical determinants of abnormal monovalent ion transport in primary hypertension.

The American journal of physiology - 1 Mar 1999

Orlov S N, Adragna N C, Adarichev V A, Hamet P

Abstract excerpt

Data obtained during the last two decades show that spontaneously hypertensive rats, an acceptable experimental model of primary human hypertension, possess increased activity of both ubiquitous and renal cell-specific isoforms of the Na+/H+ exchanger (NHE) and Na+-K+-2Cl- cotransporter. Abnormalities of these ion transporters have been found in patients suffering from essential hypertension. Recent genetic...

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PMID: 10069978
DOI: 10.1152/ajpcell.1999.276.3.C511

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