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Article

Characterization of live influenza vaccine donor strain derived from cold-adaptation of X-31 virus.

Vaccine - 10 Mar 2006

Lee Kwang-Hee, Seo Sang-Uk, Song Jae-Min, Lee Chung-Min, Kim Hyun-Ah, Seong Baik L

Abstract excerpt

A human influenza A virus X-31 (high-yielding strain) was cold-adapted for possible future use as live attenuated vaccine. Mutant influenza viruses were selected during successive serial passage in embryonated hens' eggs at progressively lower sub-optimal temperature (30, 27 degrees C followed by 24 degrees C). The cold-passaged mutant exhibited both temperature-sensitivity (ts) and cold-adapted (ca) phenotypes....

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Identifiers

PMID: 16343703
DOI: 10.1016/j.vaccine.2005.10.051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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