Characterization of live influenza vaccine donor strain derived from cold-adaptation of X-31 virus.

doi:10.1016/j.vaccine.2005.10.051

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Article

Characterization of live influenza vaccine donor strain derived from cold-adaptation of X-31 virus.

Vaccine - 10 Mar 2006

Lee Kwang-Hee, Seo Sang-Uk, Song Jae-Min, Lee Chung-Min, Kim Hyun-Ah, Seong Baik L

Abstract excerpt

A human influenza A virus X-31 (high-yielding strain) was cold-adapted for possible future use as live attenuated vaccine. Mutant influenza viruses were selected during successive serial passage in embryonated hens' eggs at progressively lower sub-optimal temperature (30, 27 degrees C followed by 24 degrees C). The cold-passaged mutant exhibited both temperature-sensitivity (ts) and cold-adapted (ca) phenotypes....

Topics

Adaptation, Physiological
Administration, Intranasal
Animals
Antibodies, Viral
Body Weight
Cell Line
Chick Embryo
Cold Temperature
Dogs
Enzyme-Linked Immunosorbent Assay
Female
Influenza A Virus, H2N2 Subtype
Influenza A Virus, H3N2 Subtype

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Influenza A virus

Influenza Vaccines

Lung

Mice

Mice, Inbred BALB C

Source

Open in PubMed

Identifiers

PMID: 16343703
DOI: 10.1016/j.vaccine.2005.10.051

Provenance

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