Article
Characterization of proteoglycan-reactive T cell lines and hybridomas from mice with proteoglycan-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1992
Leroux J Y, Poole A R, Webber C, Vipparti V, Choi H U, Rosenberg L C, Banerjee S
Abstract excerpt
Hyperimmunization with chondroitin sulfate-depleted fetal human cartilage proteoglycan (HFPG) leads to the development of peripheral arthritis and spondylitis in BALB/c mice. Chondroitin-sulfate-depleted adult human cartilage proteoglycan (HAPG) is much less effective at inducing arthritis. These observations suggest age differences in the presence of arthritogenic proteoglycan (PG) epitopes. Earlier studies from...
Topics
- Animals
- Arthritis
- Cell Line
- Epitopes
- Histocompatibility Antigens Class II
- Hybridomas
- Mice
- Mice, Inbred BALB C
- Phenotype
- Proteoglycans
- T-Lymphocytes