Article
T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles.
Arthritis and rheumatism - 1 Jul 1999
Cope A P, Patel S D, Hall F, Congia M, Hubers H A, Verheijden G F, Boots A M, Menon R, Trucco M, Rijnders A W, Sønderstrup G
Abstract excerpt
OBJECTIVE: To analyze the CD4+ T cell responses to the human cartilage antigen glycoprotein-39 (HCgp-39) in the context of rheumatoid arthritis (RA)-associated (DRalphabeta1*0401) and nonassociated (DRalphabeta1*0402) HLA class II molecules. METHODS: Large numbers of HCgp-39-specific T cell hybridomas were generated following immunization of HLA-DR4/human CD4 transgenic, murine major histocompatibility complex...
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