Article
T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles.
Arthritis and rheumatism - 1 Jul 1999
Cope A P, Patel S D, Hall F, Congia M, Hubers H A, Verheijden G F, Boots A M, Menon R, Trucco M, Rijnders A W, Sønderstrup G
Abstract excerpt
OBJECTIVE: To analyze the CD4+ T cell responses to the human cartilage antigen glycoprotein-39 (HCgp-39) in the context of rheumatoid arthritis (RA)-associated (DRalphabeta1*0401) and nonassociated (DRalphabeta1*0402) HLA class II molecules. METHODS: Large numbers of HCgp-39-specific T cell hybridomas were generated following immunization of HLA-DR4/human CD4 transgenic, murine major histocompatibility complex...
Topics
- Adipokines
- Alleles
- Animals
- Arthritis, Rheumatoid
- Autoantigens
- Cartilage
- Chitinase-3-Like Protein 1
- Cytokines
- Epitope Mapping
- Epitopes, T-Lymphocyte
- Female
- Glycoproteins
- HLA-DR4 Antigen