Article
The canine copper toxicosis gene MURR1 is not implicated in the pathogenesis of Wilson disease.
Journal of gastroenterology - 1 Jun 2006
Lovicu Mario, Dessì Valeria, Lepori Maria Barbara, Zappu Antonietta, Zancan Lucia, Giacchino Raffaella, Marazzi Maria Grazia, Iorio Raffaele, Vegnente Angela, Vajro Pietro, Maggiore Giuseppe, Marcellini Matilde, Barbera Cristiana, Kostic Vladimir, Farci Anna Maria Giulia, Solinas Antonello, Altuntas Buket, Yuce Aysel, Kocak Nurten, Tsezou Aspasia, De Virgiliis Stefano, Cao Antonio, Loudianos Georgios
Abstract excerpt
BACKGROUND: It has recently been demonstrated that the Wilson disease (WD) protein directly interacts with the human homolog of the MURR1 protein in vitro and in vivo, and that this interaction is specific for the copper transporter. The aim of the present study was to clarify the role of MURR1 in the pathogenesis of WD as well as in other WD-like disorders of hepatic copper metabolism of unknown origin. METHODS:...
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