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Article

The Copper Toxicosis Gene Product Murr1 Directly Interacts with the Wilson Disease Protein

1 Oct 2003

Abstract excerpt

Copper toxicosis in Bedlington terriers is an autosomal recessive disorder characterized by excessive hepatic copper accumulation in association with a marked decrease in biliary copper excretion. Recent genetic data have revealed that MURR1, a single copy gene on dog chromosome 10q26, is mutated in this disorder. This gene encodes a 190-amino acid open reading frame of unknown function that is highly conserved...

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PMID: 12968035
DOI: 10.1074/jbc.c300391200

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Related research

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Research trail→

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The Copper Toxicosis Gene Product Murr1 Directly Interacts with the Wilson Disease ProteinPMID 12968035Read ↗

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Characterization of the COMMD1 (MURR1) mutation causing copper toxicosis in Bedlington terriers.Semantic proximity Read ↗

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Indirect molecular diagnosis of copper toxicosis in Bedlington terriers is complicated by haplotype diversity.Semantic proximity Read ↗

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