Article
PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function.
The Journal of biological chemistry - 29 Sept 2006
Yesilaltay Ayce, Kocher Olivier, Pal Rinku, Leiva Andrea, Quiñones Verónica, Rigotti Attilio, Krieger Monty
Abstract excerpt
PDZK1 is a multi-PDZ domain-containing adaptor protein that binds to the C terminus of the high density lipoprotein receptor, scavenger receptor, class B, type I (SR-BI), and controls the posttranscriptional, tissue-specific expression of this lipoprotein receptor. In the absence of PDZK1 (PDZK1(-/-) mice), murine hepatic SR-BI protein levels are very low (<5% of control). As a consequence, abnormal plasma...
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