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Article

Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein.

The American journal of physiology - 1 Feb 1999

Xie C, Turley S D, Pentchev P G, Dietschy J M

Abstract excerpt

Type C Niemann-Pick disease is due to a mutation in Niemann-Pick C (NPC) protein, a putative determinant of intracellular cholesterol transport. This study quantifies cholesterol balance in vivo across all tissues in mice with this defect. Cholesterol balance in the heterozygous animal is normal, but in the homozygous mouse the whole animal cholesterol pool expands continuously from birth, reaching 5, 442 mg/kg...

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Identifiers

PMID: 9950794
DOI: 10.1152/ajpendo.1999.276.2.E336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein.PMID 9950794Read ↗

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