Article
Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein.
The American journal of physiology - 1 Feb 1999
Xie C, Turley S D, Pentchev P G, Dietschy J M
Abstract excerpt
Type C Niemann-Pick disease is due to a mutation in Niemann-Pick C (NPC) protein, a putative determinant of intracellular cholesterol transport. This study quantifies cholesterol balance in vivo across all tissues in mice with this defect. Cholesterol balance in the heterozygous animal is normal,...
Topics
- Animals
- Brain
- Cholesterol
- Cholesterol, Dietary
- Heterozygote
- Homozygote
- Intracellular Signaling Peptides and Proteins
- Liver
- Mice
- Mice, Inbred BALB C
- Mutation
- Niemann-Pick C1 Protein
- Proteins
- Sterols
- Tissue Distribution