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Article

Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease.

American journal of physiology. Heart and circulatory physiology - 1 Dec 2016

Pal Rinku, Ke Qingen, Pihan German A, Yesilaltay Ayce, Penman Marsha L, Wang Li, Chitraju Chandramohan, Kang Peter M, Krieger Monty, Kocher Olivier

Abstract excerpt

The HDL receptor SR-BI mediates the transfer of cholesteryl esters from HDL to cells and controls HDL abundance and structure. Depending on the genetic background, loss of SR-BI causes hypercholesterolemia, anemia, reticulocytosis, splenomegaly, thrombocytopenia, female infertility, and fatal coronary heart disease (CHD). The carboxy terminus of SR-BI (505QEAKL509) must bind to the cytoplasmic adaptor PDZK1 for...

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Source

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Identifiers

PMID: 27694217
DOI: 10.1152/ajpheart.00463.2016
PMCID: PMC5206344

Genes

PDZK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease.PMID 27694217Read ↗

Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and AtherosclerosisSemantic proximity Read ↗

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Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.Semantic proximity Read ↗

Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues.Semantic proximity Read ↗

Scavenger receptor class B type I is a plasma membrane cholesterol sensor.Semantic proximity Read ↗

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A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism.Semantic proximity Read ↗

PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function.Semantic proximity Read ↗

SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE. Structural mutations in SR-BI diminish cholesterol efflux.Semantic proximity Read ↗

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